Nanotechnologies for Solubilization and Delivery in Foods, Cosmetics and Pharmaceuticals

Edited by: Nissim Garti and Idit Amar-Yuli, The Hebrew University of Jerusalem

ISBN: 978-1-60595-016-7, ©2012, 401 pages, 6×9, Hardcover

Edited by: Nissim Garti and Idit Amar-Yuli,
The Hebrew University of JerusalemISBN: 978-1-60595-016-7, ©2012, 401 pages, 6×9, Hardcover
  • New strategies for designing drug and nutrient delivery systems
  • Micellar and reverse micellar techniques for synthesizing nanocarriers and particles
  • Novel vehicles from lipids, biopolymers, gels, dendrimers and more
  • Methods for better solubility, penetration, absorption and bioavailability of bioactives

Beginning with the basics of surfactant chemistry and micellization, this book presents a range of nanotechnology strategies for controlling colloidal and polymeric structures for the solubilization and targeted delivery of food nutrients and pharmaceuticals. The book demonstrates how vehicles for delivering bioactive ingredients through a variety of oral, transdermal, buccal and mucosal routes, can be synthesized by nanolevel manipulation of colloidal systems, proteins, peptides, liquid crystalline phases, organogels and dendrimers. Special attention is given to the modification of mesophases in micellar and liquid crystal systems, which are shown to be productive templates and chemical nanoreactors for uniquely structured nanocarriers. The volume connects micro- and nanolevel modification of emulsion-based and biopolymeric systems, as well as the formation of new nanoparticles, to key properties of absorption, bioavailability and therapeutic effectiveness for dozens of well-known and experimental drugs, food nutrients and antimicrobials. Throughout, a stress is placed on chemical strategies for enhancing the efficiency of drug and nutrient carriers. The information presented in this book is applicable to the design of micro- and nanolevel delivery systems with improved targeting, more efficient controlled release, and superior in vivo penetration into dermal and cellular structures.

Preface

Chapter 1. Surfactants in Solution—Basic Concepts
Shmaryahu Ezrahi, Abraham Aserin, Rivka Efrat,
Dima Libster, Eran Tuval, and Nissim Garti

  • Introduction
  • Interface
  • Interfacial (surface) Energy
  • Surface Tension
  • Surfactants
  • Micelles and Micellization
  • Liquid Crystals
  • Intermediate Phases
  • Sponge (L3) Phases
  • Microemulsions
  • Summary
  • References

Chapter 2. Micelle Formation: Thermodynamic Aspects and Characterization
Massimo Bonini and Pierandrea Lo Nostro

  • Introduction
  • Thermodynamic Aspects
  • Characterization
  • Conclusions and Outlook
  • References

Chapter 3. Microemulsions—Characterization and Selected Applications
Shmaryahu Ezrahi, Dima Libster, Abraham Aserin,
Rivka Efrat, Eran Tuval, and Nissim Garti

  • Introduction
  • The Definition of Microemulsion
  • Microemulsions vs. Emulsions
  • Microemulsions vs. Nanoemulsions
  • The Mechanism of Microemulsions Stability
  • Microstructures of Microemulsions
  • Characterization of Microemulsions
  • Phase Behavior
  • Applications
  • Summary
  • References

Chapter 4. Development of Colloidal Delivery Systems for Food and Pharmaceutical Applications Based on Proteins and Polysaccharides
Owen Griffith Jones and D. Julian McClements

  • Introduction
  • Biopolymer Materials
  • Interactions Responsible for Assembly of Biopolymer Aggregates
  • Assembly Principles
  • Processing Methods
  • Cross-linking Methods
  • Conclusion
  • References

Chapter 5. Protein- and Lipid-Based Nano- and Micro-Capsules, as Food Micronutrient Carriers
Perla Relkin and Marc Anton

  • Introduction
  • Protein-Stabilized Particles as Food Nutrient Carriers
  • Nano- or Fine-Lipid Droplets as Food Matrix Carriers
  • LDL—a Natural Nanocapsule to Vectorise Micronutrients
  • Conclusion
  • References

Chapter 6. Topical Delivery of Pharmaceuticals using Liquid Crystalline Structures
Dima Libster, Abraham Aserin, and Nissim Garti

  • Liquid Crystals
  • LLC as Drug Delivery Vehicles
  • Hexagonal and Cubic Mesophases and Their Dispersions as Carriers of Hydrophilic Drugs
  • Delivery of Lipophilic Drugs from LLC Systems
  • Conclusion
  • References

Chapter 7. Recent Advances in the Characterization of Lipid-Based Nanocarriers
Anan Yaghmur and Michael Rappolt

  • Introduction
  • Self-Assembly in Soft Lipidic Formulations
  • Potential Applications as Nanocarriers in Food and Pharmaceutical Industries
  • Recent Advances in the Characterization of Soft Self-Assembled Systems
  • Future Challenges and Perspectives
  • References

Chapter 8. Interfacial Reactivity at Liquid Crystal Interfaces
Idit Amar-Yuli, Abraham Aserin, and Nissim Garti

  • Introduction
  • Nanoparticles Synthesis—Liquid Crystalline Phases Perform as Templates
  • Conclusions
  • References

Chapter 9. Structured Organogels Based on Vegetable Oils and Surfactants-Structures, Characteristics and Applications
Edmund Co and Alejandro G. Marangoni

  • The Gel State
  • Phytosterol Vegetable Oil Organogels
  • Phospholipid Microemulsion Organogels
  • Wax-Based Organogels
  • 2-Hydroxystearic Acid Vegetable Oil Organogels
  • References

Chapter 10. Characterization and Therapeutic Applications of Immunonanoparticles as Targeted Drug Delivery Systems: A Focus on Cancer Therapy
Nir Debotton and Simon Benita

  • Introduction
  • Nanoparticles
  • NPs as Drug-Delivery Systems for Cancer Therapy
  • Targeting of NPs
  • Monoclonal Antibodies
  • Tumor Cell Antigen Overexpression
  • Approaches for ImmunoNP Preparation
  • Therapeutic Applications of ImmunoNP
  • Conclusions
  • References

Chapter 11. Embedding Antibacterial Inorganic Nanoparticles and Proteinaceous Microspheres in Textiles by a Sonochemical Method
N. Perkas, A. Gedanken, I. Perelshtein, and U. Angel

  • A Sonochemical Method for the Synthesis of Nanostructured Materials and their Adherence to Solid Substrates
  • Antibacterial Finishing of Textiles with Nanoparticles
  • Embedding Nanosilver into Different Kinds of Textiles by the Sonochemical Technique
  • Ultrasound Assisted Deposition of Metal Nanooxides on Textiles and Their Antibacterial Properties
  • Sonochemical Synthesis of Proteinaceous Microspheres and their Deposition on the Textiles
  • Conclusion
  • References

Chapter 12. Dendrimeric Polymers for Pharma Applications—Anti-Cancer Therapies
Barbara Klajnert and Maria Bryszewska

  • Introduction
  • Receptor-Based Targeted Delivery
  • Enhanced Permeation and Retention Effect
  • pH-Targeted Delivery and Photochemical Internalization
  • Cancer Gene Therapy
  • Intrinsic Anti-cancer Activity
  • Photodynamic Therapy
  • Boron Neutron Capture Therapy
  • Radiotherapy with Dendrimers
  • Conclusions
  • References

Index

Nanotechnologies for Solubilization and Delivery in Foods, Cosmetics and Pharmaceuticals (Entire eBook)
$145.00 Save: $30.00
Chapter 1: Surfactants in Solution—Basic Concepts
$25.00
Chapter 2: Micelle Formation: Thermodynamic Aspects and Characterization
$25.00
Chapter 3: Microemulsions—Characterization and Selected Applications
$25.00
Chapter 4: Development of Colloidal Delivery Systems for Food and Pharmaceutical Applications Based on Proteins and Polysaccharides
$25.00
Chapter 5: Protein- and Lipid-Based Nano- and Micro-Capsules, as Food Micronutrient Carriers
$25.00
Chapter 6: Topical Delivery of Pharmaceuticals using Liquid Crystalline Structures
$25.00
Chapter 7: Recent Advances in the Characterization of Lipid-Based Nanocarriers
$25.00
Chapter 8: Interfacial Reactivity at Liquid Crystal Interfaces
$25.00
Chapter 9: Structured Organogels Based on Vegetable Oils and Surfactants-Structures, Characteristics and Applications
$25.00
Chapter 10: Characterization and Therapeutic Applications of Immunonanoparticles as Targeted Drug Delivery Systems: A Focus on Cancer Thera
$25.00
Chapter 11: Embedding Antibacterial Inorganic Nanoparticles and Proteinaceous Microspheres in Textiles by a Sonochemical Method
$25.00
Chapter 12: Dendrimeric Polymers for Pharma Applications—Anti-Cancer Therapies
$25.00

ISBN: 978-1-60595-016-7, ©2012, 401 pages, 6×9, Hardcover

Edited by: Nissim Garti and Idit Amar-Yuli,
The Hebrew University of JerusalemISBN: 978-1-60595-016-7, ©2012, 401 pages, 6×9, Hardcover
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